Proper nutrient management practices along with use of bio-fertilizers can together not just reduce the cost of cultivation but also the quality of produce. Therefore, the present experiment was conducted to analyze the effect of different levels of nitrogen, phosphorus and bio-fertilizer on yield of irrigated wheat under conserve moisture condition during rabi season of the year 2016-17 and 2017-18 on medium black highly saline soil at Agricultural Research Station, Anand Agricultural University, Arnej, Bhal and Coastal Zone-VIII, Gujarat, India. Eight treatment combinations comprising of four levels of nitrogen (N1: 60 kg N/ha, N2: 60 kg N/ha + Bio NPK, N3: 90 kg N/ha and N4: 120 kg N/ha) and two levels of phosphorus (P: 30 kg PO/ha and P: 60 kg PO/ha) were 125225 laid out in a Randomized Block Design (factorial) with four replications. The application of 120 kg N/ha gave significantly highest grain yield compared to the rest of treatments. Significantly the highest grain yield of 2349, 2430 and 2389 kg/ha recorded during 201617, 2017-18 and in pooled data, respectively. While in case of phosphorus levels, application of 60 kg P2O5/ha recorded significantly the highest grain yield of 2340, 2465 and 2402 kg/ha during 2016-17, 2017-18 and in pooled data, respectively. It could be concluded that for obtaining maximum grain yield of wheat, application of 120 kg N/ha and 60 kg P2O5/ha from which 50 % should be applied as basal, 25% at 30 days after sowing (DAS) and remaining 25% after 45 DAS through urea and di-ammonium phosphate fertilizers.