The most common broadleaf weed infesting the experimental site in both the years was common lambsquarters (Chenopodium album L). Two field trials were performed in south of Russia in two growing seasons 2014 and 2015 for illustrating the efficacy of different post-emergence herbicide combinations in spring wheat cultivars. Common lambsquarters suppression was appropriate with metsulfuron and whole herbicide including metsulfuron. The lowest common lambsquarters suppression was for aminopyralid/florasulam, common lambsquarters had average response to the other tested treatments. Metsulfuron+fluroxypyr applied in spring wheat had the greatest result for wheat grain yield enhancement. Hence, metsulfuron and treatments involving metsulfuron caused the highest common lambsquarters reduction in comparison with other treatments examined in the experiments, and consistently maintained favourable spring wheat yields for both the years. Metsulfuron can improve common lambsquarters resistance to herbicides in wheat field of Russian Federation prairies.