Common lambsquarters (Chenopodium album) is a worldwide weed species growing in cropping system. Two trials were performed between 2015 and 2016 to evaluate applications of ALS inhibitor herbicides for common lambsquarters control and crop safety in spring wheat. The formulated mixture of the (iodosulfuron/mesosulfuron/antidote mefenpyr-diethyl) and tribenuron provided the highest value of labsquarters reduction in both the experiments. Results indicated that poor labsquarters control was attained when triasulfuron was applied at the rate of 20 g a. i./ha. In both the experiments, effective control of labsquarters resulted in substantial increases in wheat yields with the average value of Rs. 7700 kg/ha. Hence, the formulated combination of (iodosulfuron/mesosulfuron/antidote mefenpyr-diethyl) and tribenuron provided the highest level of labsquarters suppression and these herbicides were consistently associated with the highest wheat yield response. It can be concluded that these active ingredient combinations can effectively be applied in wheat for common lambsquarters control in spring growing season. Mentioned research evaluated some ALS inhibitor herbicides that were effective for use in wheat production.