An experiment was carried out during rabi seasons of 2014–15 and 2015–16 on sandy loan soil at AICRP-WM farm, AAU, Anand to access the bio-efficacy and economics of premix broad spectrum herbicides for control of complex weed flora in wheat. Significantly lower weed density, dry biomass of weeds and higher grain and straw yields as well as net returns were achieved with application of pre-mix sulfosulfuron (75%)+metsulfuron methyl (5% WG) @ 32 g/ha POE, clodinafop (15%)+metsulfuron methyl (1% WP) @ 64 g/ha PoE and mesosulfuron (3%)+iodosulfuron methyl sodium (0.6% WDG) @ 14.4 g/ha PoE as compared to rest of the treatments. However, mesosulfuron (3%)+iodosulfuron methyl sodium (0.6% WDG) @ 14.4 g/ha PoE showed phytotoxic effect on wheat at seven days after application.