The research work was conducted to study the comparative efficacy of different herbicides on Bt cotton and their residual effect on succeeding crops during kharif seasons of the years 2010, 2011 and 2012 at the farm of DWSR-Anand Centre, B. A. College of Agriculture, Anand Agricultural University, Anand (Gujarat). Inter-culturing in conjunction with hand weeding carried out at 15, 30 and 45 DAS recorded minimum weed density with maximum weed control efficiency. The said treatment also recorded maximum seed cotton yield (3127 kg/ha) as well as additional profit over control (Rs. 46367/ha). The next best treatments in order: T1-Pendimethalin @ 900 g/ha fb IC+HW at 30 and 60 DAS, T2-Quizalofop-ethyl 50 g/ha POE fb IC+HW at 30 DAS and T5-Fenoxaprop-p-ethyl 50 g/ha POE fb IC+HW at 30 DAS were found efficient and economical for weed management in Bt cotton. None of the herbicides applied at tested rates had adverse effect on succeeding wheat, chickpea and mustard crops.