This study analyzes the content of mineral elements Ca, Mg, K, Cu, Zn, Mn and Fe in tobacco-planting soils and tobacco leaves from Yunnan, Guizhou, Chongqing, etc. Six main tobacco-producing areas in China aimed at analyzing the correlation between mineral elements and main chemical components and smoking quality. The linear regression and multiple regression equation about chemical composition and the smoking quality were established. Correlation analysis indicated that there was certain degree of synergistic or antagonistic relationship between contents of mineral elements in tobacco-planting soils and contents of corresponding elements in tobacco leaves. Among mineral elements, magnesium and potassium were found most influencing to the smoking quality of tobacco. Based on the actual situation of mineral contents in soils from different tobacco-producing areas, contents of various elements in tobacco leaves should be regulated by soil fertilization and foliar spraying, thereby improving the aroma quality of flue-cured tobacco.