A field experiment conducted during 2012–13 and 2013–14 at Gadag, Karnataka, India to study on-farm response of groundnut (Arachis hypogaea)-sorghum (Sorghum bicolor) cropping system to fertilizers NPK input revealed that application of 25 kg N, 50 kg P2O5, 25 kg K2O and 25 FeSO4 kg/ha to groundnut and 50 kg N, 25 kg P2O5 0 kg K2O and 15 kg ZnSO4/ha to sorghum recorded significantly higher pod/grain and haulm/stover yields. Groundnut pod equivalent yield (1743 kg/ha), net returns (Rs. 43, 892/ha), benefit: cost ratio (4.58) and total NPK uptake (140.96 kg/ha) by groundnut-rabi sorghum cropping system were also higher in recommended dose of fertilizers (T6) over rest of the treatments. This treatment also recorded the maximum production efficiency (8.11kg/ha/day) and nitrogen use efficiency (32.24 kg/kg) in groundnut and 14.56 kg/kg in rabi sorghum. Response studies indicated that maximum response was noted with NP in groundnut (7.57 kg/kg) and NPK+ZnSO4 in sorghum (8.09 kg/kg).