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Based on the experience acquired and transmitted during the courses of generations, people came to know that some plants may alleviate numerous diseases and promote their cure. This article makes an overview of research conducted during recent years on various aspects particularly active substances and bitter ingredients in some medicinal plants have been described. The purpose of this article is to provide information on the active substances and bitter ingredients in some medicinal plants, which can be used as a reference by all those stake holders who are dealing with medicinal plants.