To evaluate the predatory efficacy of Coccinella septempunctata on rose aphid (Macrosiphum rosae), a lab experiment was escorted at 27C at laboratory of Systematics and Entomology, University of Gujrat, Gujrat during 2016. C. septempunctata is one of the most common indigenous predators of the sucking insect-pests such as aphids. Effect of some commonly used insecticides like imidacloprid and clothianidin (telsta) was tested. Mortality of adult C. septempunctata at 24 and 48 h was observed. Clothianidin was a bit more toxic insecticide as compared to imidacloprid with LC 50 value of 0.039593 ppm and LC 90 value of 0.145805 ppm. Results showed that maximum mortality i. e. 100.00% occurred at 48 h by using 0.7% concentration of telsta. While mortality rate was 75.00% at 48 h by using 0.7% concentration of imidacloprid. So, we can say that telsta is more toxic. Minimum mortality i. e. 8.3333% occurred at 24 h by using 0.1% concentration of telsta. While mortality rate was 12.500% at 24 h by using 0.1% concentration of imidacloprid.