This study was conducted at Department of Zoology, University of Gujrat, Pakistan during 2016–17 as a term paper for Master of Philosophy. The data regarding effects and treatment of various types of sucking insect-pests by neonicotinoids were obtained and compiled through a thorough review of various published research articles of international reputed journals and relevant books. Neonicotinoids are a class of neuroactive insecticides, which are similar to nicotine in their chemical composition. These are very effective against insects, some chewing insects, soil insects as well as fleas on domestic animals. Neonicotinoids are basically systemic with particular efficacy against sucking insects and have a long residual activity. Neonicotinoids basically interfere with the neural transmission in central nervous system. They act as agonists by binding to the nicotine acetylcholine receptors (nAChR). These neonicotinoids act as insect neurotoxin.