Mango is being used for centuries to treat a number of diseases like, fever, diarrhea, fainting, abnormality of lymph node, and diabetes. The mango parts are shown to contain flavonoids, tannins, alkaloids, terpenoids, anthraquinones, saponins, cardiac glycosides, steroids and many more bioactive compounds; mangiferin being one of its major compounds. The different parts of mango (bark, leaves, fruits, pulp, peel, kernel, flowers) are proven to exhibit anthelmintic, anti-bacterial, anti-bone resorption, anticancer, anti-diabetic, anti-diarrheal, anti-fungal, anti-HIV, anti-hyperlipemic, antiinflammatory, anti-microbial, antioxidant, anti-parasitic, anti-pyretic, anti-plasmodial, anti-spasmodic, anti-viral, gastro-protective, hepato-protective, hypoglycemic, hypolipidemic, and immuno-modulatory and hypolipidemic properties. These pharmacological properties of mango are due to the bioactive compounds present in the different mango parts. In literature several reviews appeared dealing with the bioactive compounds present in the different mango parts and their bioactivities. However, these reviews are confined to either a few mango parts or a few bioactivities. In the present review the bioactive compounds of the different mango parts and their different bioactivities are considered in detail. This review would be helpful in the further research on the mango phytochemicals, their bioactivities and the development of herbal medicine based on mango.