The powdery mildew, Oidium mangiferae Berthet, anthracnose, Colletotrichum gloeosporoides and sooty mould Capnodium spp. are the major diseases of mango in hot and humid coastal Konkan region of Maharashtra which causes severe losses in short span of period. The mango grower uses various pesticides for their management. However, the pesticides residue and their hazardous effect are well known. Therefore, most of the mango growers in the region are switching towards organic farming and trying variety of bio-organics especially against blossom diseases of mango and claiming their effectivity. Hence, the studies on efficacy of various bio-organics were conducted at Regional Fruit Research Station, Vengurla, Dist. Sindhudurg (M.S) during 2019–20 and 2020–21 cropping seasons. The profusely flowered plants were selected and sprayed with respective bioorganic at its full bloom stage. Only one spray was given at full bloom stage. The observations on natural incidence of powdery mildew, anthracnose and sooty mould on panicles were recorded. It was revealed from the pooled results of 2019–20 and 202021seasons that, the powdery mildew, anthracnose and sooty mould diseases were significantly controlled only by the treatments of chemical check Carbendazim 12% + Mancozeb 63% WP @ 0.2%. However, among the treatments of bio-organics Jeevamrut @10% and Vermiwash @ 10% were found promising against major diseases of mango blossom.