The present investigation was conducted at KRC College of Horticulture, Arabhavi, Karnataka during kharif season of 2016 and 2017 to evaluate the bio-efficacy of different insecticides (profenophos, buprofezin, spinosad, chlorantraniliprole, thiamethoxam, acephate, malathion) along with aqueous NSKE @ 5% and azadirachtin 1500 ppm against leaf miner, Liriomyza trifoii (Burgess) on ridge gourd. The results of pooled data revealed that spinosad 45 SC @ 0.3 ml/l was most effective in reducing leaf miner followed by chlorantraniliprole 18.5 SC @ 0.20 ml/l and thiamethoxam 25 WG @ 0.25 g/l. The highest yield was recorded in spinosad 45 SC @ 0.3 ml/l (103.75 q/ha) which was found to be at par with chlorantraniliprole 18.5 SC @ 0.20 ml/l (98.48 q/ha) followed by thiamethoxam 25 WG @ 0.25 g/l (88.71 q/ha).