A field experiment was conducted during kharif 2010 at Agricultural College Farm, Raichur to study the effect of macro and soluble micronutrients on growth and yield of Bt cotton (Gossypium hirsutum L.) under irrigation. The results revealed that application of 125% RDF in combination with 0.5% tracel micronutrient recorded the highest seed cotton yield, lint index, uptake of nitrogen and phosphorus and gross returns (19.88 q/ha, 96.99 g/plant, 5.20 and 32.34 kg/ha and Rs. 79,533/ha, respectively), whereas in absence of foliar nutrition with 100% RDF recorded the lowest seed cotton yield, lint index, uptake of nitrogen and phosphorus and gross returns (12.12 q/ha, 59.09 g/plant, 4.69, 88.13 and 18.51 kg/ha and Rs. 48,462/ha, respectively), but application of 125% RDF with the foliar spray of 1% mangala MgSO4 recorded the highest ginning percentage (34.70) and application of 100% RDF without foliar spray recorded the lowest ginning percentage (32.67), whereas application of 125% RDF with the foliar spray of 0.5% tracel micronutrient recorded the highest uptake of potassium (115.52 kg/ha) and lowest uptake (89.58 kg/ha) in absence of water soluble micronutrients when compared to RDF levels and foliar spray of water soluble micronutrients alone.