A field experiment was conducted during kharif and summer seasons of 2010–11 at ZARS, V. C. Farm, Mandya, Karnataka to study the effect of methods of cultivation and fertility levels on nutrient uptake of rice hybrids. The experiment involving methods of cultivation (SRI and conventional method of planting), rice hybrids (KRH-2, KRH-4 and Arize (6444) and fertility levels (100% RDF, 125% RDF and 150% RDF) was laid out in double split-plot design with three replications. The results revealed that SRI method of planting recorded significantly higher NPK uptake by grain (77.42, 21.77 and 61.46 kg/ha, respectively) with rice hybrid Arize (81.41, 25.46 and 61.84 kg/ha) at 150% RDF (76.91, 22.68 and 61.46 kg/ha, respectively). Significantly higher grain yield was obtained under SRI method of planting (7717 kg/ha) with rice hybrid Arize (7808 kg/ha) at 150% RDF (7821 kg/ha).