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Research on Crops

Evaluation of in vitro antimicrobial and antioxidant activities of Scutellaria baicalensis Georgi 


DOI: 10.31830/2348-7542.2026.ROC-1292    | Article Id: ROC-1292 | Page : 179-186
Citation :- Evaluation of in vitro antimicrobial and antioxidant activities of Scutellaria baicalensis Georgi. Res. Crop. 27: 179-186
HEE MOON, KYOUNG-SUN SEO AND KYEONG WON YUN ykw@scnu.ac.kr
Address : Department of Bio-Oriental Medicine Resources, Sunchon National University, Suncheon 57922, Republic of Korea
Submitted Date : 5-02-2026
Accepted Date : 6-03-2026
Online Published:

Abstract

The root of Scutellaria baicalensis Georgi has been used as an oriental medicine resource for heat patterns with high fever. The current study is aimed at assessing in vitro antimicrobial and antioxidant activity of S. baicalensis. The disc diffusion and minimal inhibitoty concentration (MIC) method was used to measure the antimicrobial activity of three fractions of ethanol extract from S. baicalensis against three Gram-positive strains, three Gram-negative strains and one yeast. The ether and ethyl acetate fraction of root extract from S. baicalensis demonstrated the lowest MIC value of 0.5 mg/ml or 1.0 mg/ml against the tested microorganisms. All of the tested fractions of the root and shoot exhibited lower MIC value against Bacillus cereus, Bacillus subtilis, and Candida albicans; on the other hand, Lactobacillus brevis and Escherichia coli were not detected for MIC against any tested fractions. The antioxidant activity of the plant was evaluated by DPPH and ABTS radical scavenging assay. The 70% ethanol extract of the shoot had an IC50 value of 274.84±6.78 µg/mL against DPPH and 103.95±2.82 µg/mL against ABTS, while the 70% ethanol extract of the root had an IC50 value of 302.71±7.82 µg/mL against DPPH and 115.45±3.16 µg/mL against ABTS. The 70% ethanol extract of the shoot exhibited the highest antioxidant activity and the highest total phenolic and flavonoid contents. The root fraction exhibited higher antimicrobial activity than the shoot fraction; on the other hand, the shoot extract exhibited higher antioxidant activity than the root extract. Therefore, the shoot of Scutellaria baicalensis, like the roots, has the potential for natural resources for the food and pharmaceutical industry.

Keywords

Antimicrobial activity antioxidant activity flavonoid content phenolic content Scutellaria baicalensis 

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