“Katta” and “Korme” soybean varieties were released for high yields, better stability performance and higher contents of oil and proteins. Currently, introduced blended fertilizer have not been tested for these varieties which can possibly reach the potential when provided in optimum. Therefore, this study was aimed to conduct the response of soybean varieties to NPS fertilizer rates at Western Ethiopia during 2019 to 2020 cropping season. The treatment consists of two varieties of soybean (“Korme” and “Katta”) and six rates of NPS (0, 50, 75,100, 125 and 150 kg/ha). The experiment was laid out in factorial arrangement in randomized complete block design with three replications. Results revealed that, nodule parameters were highly influenced (P<.001) by the main effect of NPS chemical fertilizer levels. Higher grain yield (2390 kg/ha) was obtained from application of 100 kg NPS/ha and there was no significant difference (P>0.05) between varieties on the grain yield. Therefore, both varieties of soybean with the application of 100 NPS kg/ha is suggested for the farmers of the study area. For future work, it is recommended to go studies the agronomic demonstration under farmers’ field, the nutritional quality of soybean for oil and feed for poultry.