In Samara region, potato growing season is characterized by the elevated stress effect on plants. The main limiting factors include increased temperature regime, soil and air drought, and high infectious background. Therefore, a 4-year study conducted during 2015 to 2018 at Samara Federal Research Scientific Center, Bezenchuk, Russia on domestic and foreign selection potato varieties in Samara region. The experiment included 30 varieties: ten early-ripening, ten middle-early, and ten mid-season-ripening and middle-late varieties. It was shown that the average productivity of the middle-early variety group was significantly higher than that of early-ripening and mid-season-ripening varieties. The minimum variability of the yield indicator was also noted in the group of middle-early varieties. When using the method of integral assessment of the varieties by a complex of economically valuable indicators, it was found that in local agroecological conditions, the middle-early varieties have an advantage over plants of the other ripeness groups. The best middle-early varieties Sparta, Arosa and Yubilej Zhukova that were characterized by a combination of high yields and high resistance to viral and fungal diseases were identified and recommended for cultivation.