Cantaloupe (Cucumis melo) fruit contains high nutritional components, especially appreciable amounts of micronutrients, antioxidants and minerals with variety of therapeutic attributes. 1-methylcyclopropene (1-MCP) is an ethylene antagonist by preventing ethylene performance via binding effectively to ethylene receptors in plant tissue. This research evaluated the effectiveness of 1-methylcyclopropene in different concentration (0, 25, 50, 75 and 100 ppm) to antioxidant behaviours (total phenolic, flavonoid, DPPH, ABTS and FRAP radical-scavenging activity) of cantaloupe fruits during 28 days at ambient temperature storage. This study was conducted in 2019 in Labone Scientific Co. Ltd, Vietnam. The use of this agent at 75 ppm maintained the shelf-life and phytochemical quality of cantaloupe fruit during preservation.