Corynespora leaf fall disease (CLF), caused by the fungus Corynespora cassiicola (Berk. & Curt.) Wei, has occurred and become a serious disease on rubber (Hevea brasiliensis) in Asian countries, including Vietnam. Field experiments were conducted in order to evaluate the efficacy of four chemical fungicides difenoconazole, difenoconazole+propiconazole, epoxiconazole and tebuconazole for controlling CLF in Thua Thien Hue province, Central Vietnam. These insecticides were applied at recommended field rates. The results showed that all the four tested fungicides were moderate or high efficacy against CLF. The efficacy was highest with difenoconazole (64.4–71.5%) on rubber planted at both the two different ecological zones. These results suggest that difenoconazole application provides one potential component of an effective CLF control strategy for rubber farmers.