A fie1d experiment was implemented at Vegetable field, Department of Plant Production, Agricultural Technical College, Mosul, Iraq during spring season of 2018 to study the response of four potato cultivars (Actrice, Arizona, Riviera and Universa) to four organic and amino acid compounds (Azomine 4 ml/l, Tecamin Max 3 ml/l, Delfan plus 3 ml/l and Humibest 4 g/l) as soil application. The experiment was subjected in a factorial experiment in randomized complete block design with three replications. The results revealed that the cultivar (Riviera) gave the highest shoot number, fresh and dry weight of plant, leaf area, total chlorophyll content, tuber number per plant, plant yield and total yield. Application of Azomin as amino acid compound increased dry weight of plant, leaf area, total chlorophyll content, tuber number per plant, average tuber weight, total yield, starch percentage, N and P content in tuber significantly than other amino acid compounds. On the other hand, the interaction treatments between cultivars and organic and amino acid compounds resulted in a significant effect in many studied parameters.