The main aim of this study was to evaluate the effect of saline water, chemicals and organic fertilizers on lettuce (Lactuca sativa L.) growth, its yield and their antioxidant and soil properties. There were two experiments, one was soil, and another was lettuce growth parameters with anti-oxidant enzyme activities by using split-plot design method. Study findings showed the soil properties, the effect of saline water and rice wastes on some soil characters in the first experiment. And the second experiment findings revealed that the higher effect of overall yield, chlorophyll, NPK content, antioxidant enzymes and proline, higher POX level, increased activity of CAT, SOD level, maximum accumulation of proline and dry weight of head were observed in rice wastes and DAP 400 kg/ha treatment than control.