Field experiment was conducted during kharif seasons of the years 2010, 2011 and 2012 at DWSR-Anand Centre, B. A. College of Agriculture, Anand Agricultural University, Anand (Gujarat) to study the performance of different weed management practices on weeds and yield of Bt cotton. Results revealed that inter-culturing and hand weeding carried out at 15, 30 and 45 DAS recorded the minimum weed dry weight of monocot, dicot and total weeds at 25 DAS and at harvest with maximum weed control efficiency. The said treatment also recorded maximum seed cotton yield (3127 kg/ha) as well as additional profit over control (46367 kg/ha). The next best treatments were T1 (pendimethalin @ 900 g/ha fb IC+HW at 30 and 60 DAS), T2 (quizalofop-ethyl 50 g/ha POE fb IC+HW at 30 DAS) and T5 (fenoxaprop-p-ethyl 50 g/ha POE fb IC+HW at 30 DAS) which were found efficient and economical for weed management in Bt cotton.