Three cotton (Gossypium hirsutum L.) cultivars were evaluated for their growth and yield performance in the upstream Tarim river, Xinjiang, China in 2009 and 2010. In 2009, 12090 kg cotton 10-108-3/ha beat the world's record in this area. In the following year, the output of cotton 10-108-3 yield created new world's record of 10590 kg/ha. Our studies focus on theoretical and potential factors of cotton production such as the internal and external causes of super high yield production, the damage-averse cultivation and so on. Seed and lint yields had significant positive correlations with mean net assimilation rate, ratio of reproductive to vegetative organs and mean boll weight at earlier stages of boll growth. The overall study showed the feasibility of the super high yield performance of lint cotton 10-108-3 cultivars and the technical experience in upstream Tarim river cotton region.